Phenformin hydrochloride

Product Name: Phenformin hydrochloride
CAS No.: 834-28-6
Chemical Name: Phenformin hydrochloride
Synonyms: 1-Phen;dbi-td;Insora;meltrol;usafvi-6;Glucopostin;PHENFORMIN HCL;Phenformine HCL;PhenforMin HCl API;phenforminhclno.9113
CBNumber: CB2280910
Molecular Formula: C10H16ClN5
Formula Weight: 241.72
MOL File: 834-28-6.mol

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Phenformin hydrochloride Property

Melting point:: 175-178°C
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Methanol (Slightly), Water (Slightly)
color: White to Off-White
Water Solubility: >=10 g/100 mL at 21 ºC
CAS DataBase Reference: 834-28-6(CAS DataBase Reference)
EPA Substance Registry System: Phenformin hydrochloride (834-28-6)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: DU2200000
HS Code: 29252900
Toxicity: LD50 in mice (mg/kg): 19 i.v., 450 orally; in rats: 1050 orally; in guinea pigs: 47 orally, 19 s.c. (Proske)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P7045
Product name: Phenformin hydrochloride
Purity: analytical standard
Packaging: 1g
Price: $25.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: P7045
Product name: Phenformin hydrochloride
Purity: analytical standard
Packaging: 10g
Price: $104
Updated: 2024/03/01

Cayman Chemical

Product number: 14997
Product name: Phenformin (hydrochloride)
Purity: ≥98%
Packaging: 10g
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 14997
Product name: Phenformin (hydrochloride)
Purity: ≥98%
Packaging: 50g
Price: $99
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1573
Product name: Phenformin hydrochloride
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500mg
Price: $128
Updated: 2024/03/01

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Phenformin hydrochloride Chemical Properties,Usage,Production

Description

Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus. In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling. Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently. Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.

Chemical Properties

White Crystalline Solid

Uses

erectile dysfunction therapy

Uses

It is an anti-diabetic drug from the biguanide class.

brand name

DBI (Ciba-Geigy).

General Description

White solid or powder. Formerly used as an anti-diabetic drug. Toxic (causes lactic acidosis.

Air & Water Reactions

Water soluble.

Reactivity Profile

Phenformin hydrochloride gives weakly acidic aqueous solutions. May react with strong oxidizing agents.

Fire Hazard

Flash point data for Phenformin hydrochloride are not available; however, Phenformin hydrochloride is probably combustible.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Phenformin hydrochloride Preparation Products And Raw materials

Raw materials

Dicyandiamide

Preparation Products

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Phenformin hydrochloride Suppliers

Canada 1 China 194 Germany 1 India 3 Switzerland 1 United Kingdom 7 United States 29 Global 236

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10194
Advantage: 62

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14059
Advantage: 65

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

Alfa Chemistry

Tel: +1-5166625404
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 21317
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81215950 4000-868-328
Email: customer@uwalab.com
Country: United States
ProdList: 10413
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

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View Lastest Price from Phenformin hydrochloride manufacturers

Hebei Guanlang Biotechnology Co., Ltd.

Product: Phenformin hydrochloride 834-28-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2023-02-17

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Phenformin (hydrochloride) 834-28-6
Price: US $99.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1 ton
Release date: 2021-12-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Phenformin (hydrochloride) 834-28-6
Price: US $15.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000tons
Release date: 2022-01-05

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